Understanding Diminished Ovarian Reserve: Causes, Symptoms, and Treatments Explained
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Diminished Ovarian Reserve
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What is Diminished Ovarian Reserve DOR?
Diminished ovarian reserve refers to the reduced ability of an ovary to produce eggs, affecting fertility. Commonly recognized as part of natural aging after age 30 and more pronounced by mid-40s, DOR affects approximately 10 to 30 of women facing infertility challenges.
Causes of DOR
Diminished ovarian reserve is often a result of normal aging, though can also be due to illness or genetic abnormalities. Symptoms may appear as early as age 30 and generally intensify by mid-40s. Assisted reproduction does not reverse these changes, so IVF success rates parallel natural fertility decline in the general population.
One percent of the population experiences premature ovarian flure before age 40, which affects women below their typical menopause onset age known as premature ovarian flure or premature menopause.
Screening for DOR
A variety of tests can diagnose and evaluate ovarian reserve including blood analysis measuring follicle-stimulating hormone FSH and estradiol levels on the menstrual cycle's second or third day. Levels exceeding 12 mIUmL are considered mild elevation, while values above 15 mIUmL suggest inadequate response to fertility-enhancing medication.
Anti-Mullerian Hormone AMH is a blood test that correlates with fertility potential by reflecting egg count. This hormone assists in assessing the number of eggs avlable alongside FSHestradiol blood tests and transvaginal ultrasound assessment of visible antral follicles.
Treatments for DOR
Currently, no treatments exist to slow ovarian aging or prevent decline. For diagnosed cases, the focus shifts towards accelerating conception timing or cryopreserving freezing eggs or embryos for future use.
For IVF patients with DOR, higher doses of ovarian stimulation regimens m to maximize egg retrieval. However, when the ovary fls to respond to stimulation or later to ocrine function, donor eggs are recommed for restoring reproductive potential.
The prognosis for women with diminished ovarian reserve is guarded once identified. Even in early stages, DOR reduces pregnancy success and contributes to an increased risk of miscarriages, especially as age advances.
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Diminished Ovarian Reserve Causes and Symptoms Screening Tests for Detecting DOR Treatments Options for DOR Patients IVF Success Rates with DOR Impact of DOR on Pregnancy Cryopreservation Techniques in Reproduction