In Vitro Fertilization: A Hopeful Approach for Couples Dealing with Genetic Disorders Through Preimplantation Genetic Testing

In Vitro Fertilization as an Option for Couples with Genetic Disorders: An Overview of Preimplantation Genetic Testing and Related Strategies

Abstract:

Errors in DNA often lead to genetic disorders. Advances in reproductive health technology have provided couples, especially those at risk due to a history of genetic disorders, with new hope in reducing the likelihood of their offspring inheriting such conditions. One prominent development is In Vitro Fertilization IVF, which offers an alternative pathway for families seeking healthy offspring.

The purpose of this review was to explore current strategies that utilize IVF combined with Preimplantation Genetic Testing PGT as effective options for couples dealing with genetic disorders, allowing them to enhance their chances of having children without transmitting these conditions. We conducted a comprehensive literature review using full-text, open-access articles from prestigious databases such as ScienceDirect, PubMed, and Google Scholar, focusing on publications dating back to 2013 and concluding in 2023.

Through this systematic analysis, we identified and synthesized findings from 65 articles across various scientific journals. The keywords guiding our search included in vitro fertilization, reproductive genetic disorders, PGT-A for aneuploidy testing, PGT-M for monogenic disorders, and PGT-SR for structural rearrangements.

Upon carefully examining the selected articles, we found that IVF is indeed a viable option for couples with existing or carrier status of genetic disorders. Additional procedures can be integrated after IVF, such as oocyte donation and PGT, which specifically target aneuploidy, monogenic disorders, and structural rearrangements.

The findings indicate that IVF provides a robust framework upon which various interventions are built to support couples in their quest for healthy offspring, ensuring they can make informed decisions about their reproductive futures. These methodologies offer hope for families grappling with genetic challenges by offering potential solutions to reduce the risks of transmitting genetic disorders to their children.

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In Vitro Fertilization in conjunction with Preimplantation Genetic Testing emerges as a promising avenue for couples facing genetic disorders, enabling them to pursue parenthood while minimizing the risk of passing on such conditions. This review underscores the advancements and strategies that facilitate reproductive choices for individuals carrying mutations or diagnosed with heritable disorders.

As this is an academic review article, proper citation of sources and adherence to strict formatting guidelines for referencing are crucial components in ensuring its credibility and validity within scholarly discourse.

Acknowledgments:

We ext our gratitude to all contributors whose research forms the backbone of this review. Their dedication to advancing reproductive health technology and providing solutions for couples with genetic disorders is highly commable.

References:

a list of references formatted according to standard academic citation style e.g., APA, MLA here.

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This revised version mntns the essence of the while enhancing , coherence, and precision. The language has been tlored to fit an English-speaking academic audience, with proper use of formal terminology relevant to reproductive medicine and genetic disorders.
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